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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CSNK1E All Species: 46.06
Human Site: T176 Identified Species: 77.95
UniProt: P49674 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P49674 NP_001885.1 416 47315 T176 E N K N L T G T A R Y A S I N
Chimpanzee Pan troglodytes XP_515128 385 44007 Y167 R T H Q H I P Y R E N K N L T
Rhesus Macaque Macaca mulatta XP_001113761 317 36681 F100 F N F C S R K F S L K T V L L
Dog Lupus familis XP_850168 416 47320 T176 E N K N L T G T A R Y A S I N
Cat Felis silvestris
Mouse Mus musculus Q9JMK2 416 47304 T176 E N K N L T G T A R Y A S I N
Rat Rattus norvegicus P97633 325 37477 F108 F N F C S R R F T M K T V L M
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus Q5ZLL1 416 47453 T176 E N K N L T G T A R Y A S I N
Frog Xenopus laevis Q5BP74 415 47421 T176 E N K N L T G T A R Y A S I N
Zebra Danio Brachydanio rerio Q6P3K7 409 46813 T176 E N K N L T G T A R Y A S I N
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster O76324 440 47939 T176 E N K N L T G T A R Y A S I N
Honey Bee Apis mellifera XP_395574 413 47530 T176 E N K N L T G T A R Y A S I N
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_779963 435 49455 T176 E N K N L T G T A R Y A S I N
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P42158 450 50928 T176 E N K N L T G T A R Y A S M N
Baker's Yeast Sacchar. cerevisiae P29295 494 57322 T176 E N K S L T G T A R Y A S V N
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 92.5 72.5 99.2 N.A. 98.8 56.9 N.A. N.A. 97.3 84.3 84.3 N.A. 62.7 67.5 N.A. 67.5
Protein Similarity: 100 92.5 75 99.2 N.A. 99 65.8 N.A. N.A. 98.5 88.4 88.6 N.A. 72.9 77.4 N.A. 75.4
P-Site Identity: 100 0 6.6 100 N.A. 100 6.6 N.A. N.A. 100 100 100 N.A. 100 100 N.A. 100
P-Site Similarity: 100 13.3 20 100 N.A. 100 13.3 N.A. N.A. 100 100 100 N.A. 100 100 N.A. 100
Percent
Protein Identity: N.A. N.A. N.A. 56.6 46.1 N.A.
Protein Similarity: N.A. N.A. N.A. 70 63.7 N.A.
P-Site Identity: N.A. N.A. N.A. 93.3 86.6 N.A.
P-Site Similarity: N.A. N.A. N.A. 100 100 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 0 79 0 0 79 0 0 0 % A
% Cys: 0 0 0 15 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 79 0 0 0 0 0 0 0 0 8 0 0 0 0 0 % E
% Phe: 15 0 15 0 0 0 0 15 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 0 79 0 0 0 0 0 0 0 0 % G
% His: 0 0 8 0 8 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 8 0 0 0 0 0 0 0 65 0 % I
% Lys: 0 0 79 0 0 0 8 0 0 0 15 8 0 0 0 % K
% Leu: 0 0 0 0 79 0 0 0 0 8 0 0 0 22 8 % L
% Met: 0 0 0 0 0 0 0 0 0 8 0 0 0 8 8 % M
% Asn: 0 93 0 72 0 0 0 0 0 0 8 0 8 0 79 % N
% Pro: 0 0 0 0 0 0 8 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 0 8 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 8 0 0 0 0 15 8 0 8 79 0 0 0 0 0 % R
% Ser: 0 0 0 8 15 0 0 0 8 0 0 0 79 0 0 % S
% Thr: 0 8 0 0 0 79 0 79 8 0 0 15 0 0 8 % T
% Val: 0 0 0 0 0 0 0 0 0 0 0 0 15 8 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 8 0 0 79 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _